Hur förändras pulsen vid hypovolemi chock

1. Søreide K. Epidemiology of major trauma. Br J Surg. ;96(7) 

2. Spahn DR, Bouillon B, Cerny V, et al. Management of bleeding and coagulopathy following major trauma: an updated europeisk guideline. Crit Care. ;17(2):R 

3. Pfeifer R, Tarkin fryst vatten, Rocos B, et al. Patterns of mortality and causes of death in polytrauma patients – has anything changed?

Ge hjärt-lungräddning genom att blåsa in luft med mun-mot-mun-metoden och använda händerna för att ge så kallade bröstkompressioner, så att det syresatta blodet kan cirkulera genom kroppen

Injury. ;40(9) 

4. Kutcher ME, Kornblith LZ, Narayan R, et al. A paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices. JAMA Surg. ;(9)

5. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on patients. Injury. ;38(3) 

6.

Frith D, Brohi K. The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care. ;18(6) 

7. Cap A, Hunt BJ. The pathogenesis of traumatic coagulopathy. Anaesthesia. ;(70 Suppl 1), e 

8. Guly HR, Bouamra O, Spiers M, et al. grundläggande signs and estimated blood loss in patients with major trauma: testing the validity of the ATLS classification of hypovolaemic chock.

Resuscitation. ;82(5) 

9. Brockamp T, Nienaber U, Mutschler M, et al; TraumaRegister DGU. Predicting on-going hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithms on the TraumaRegister DGU. Crit Care. ;16(4):R 

Cotton BA, Dossett LA, Haut ER, et al. Multicenter validation of a simplified score to predict massive transfusion in trauma.

J Trauma. ;69(Suppl 1):S

Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a vs a ration and mortality in patients with severe trauma.

40 % Chockbild med takykardi, hypotoni, nedsatt-upphävd diures, vasokonstriktion

JAMA. ;(5) 

Savage SA, Sumislawski JJ, Zarzaur BL, et al. The new metric to define large-volume hemorrhage. J Trauma Acute Care Surg. ;78(2)

Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. ;63(4)

Martin M, Oh J, Currier H, et al.

An analysis of in-hospital deaths at a modern combat support hospital. J Trauma. ;66(4 Suppl):S; discussion S 

Sihler KC, Napolitano LM. Complications of massive transfusion. Chest. ;(1) 

Manikis P, Jankowski S, Zhang H, et al.

Correlation of serial blood lactate levels to kroppsdel failure and mortality after trauma. Am J Emerg Med;13(6) 

Herbert HK, Dechert TA, Wolfe L, et al. Lactate in trauma: a poor predictor of mortality in the setting of alcohol ingestion. Am Surg. ;77(12) 

Davis JW, Parks SN, Kaups KL, et al. Admission base deficit predicts transfusion requirements and fara of complications.

J Trauma. ;41(5) 

blodstillande nära seriös blödning. Vårdprogram utarbetat från arbetsgrupp inom Svenska sällskapet till trombos samt blodstillande (SSTH). utgåva 2.

Neff LP, kanon JW, Morrison JJ, et al. Clearly defining pediatric massive transfusion: cutting through the dimma and friction with combat uppgifter. J Trauma Acute Care Surg.

ATLS-klassificering (ATLS = Advanced trauma life support) av hypovolemisk chock vid blodförlust är ett strukturerat sätt att bedöma patientens fysiologiska status utifrån vitalparametrar

;78(1); discussion  

Hunt H, Stanworth S, Curry N, et al. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding. Cochrane Database Syst Rev. ;(2):CD 

Da Luz LT, Nascimento B, Shankarakutty AK, et al. Effect of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review.

Crit Care. ;18(5) 

Morrison CA, Carrick MM, Norman MA, et al. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled rättegång. J Trauma. ;70(3) 

Bogert JN, Harvin JA, Cotton BA.

Damage control resuscitation. J Intensive Care tillsammans med. Epub 10 nov

Holcomb JB, sektion Junco DJ, Fox EE, et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg.

Blodförlust upp till: 10 % Patienten i regel opåverkad, ev

;(2) 

Svensen C. Omhändertagandet nära blödning efter trauma är kapabel bli förbättrad. Läkartidningen. ;(37):CDWR. 

Peyrou V, Lormeau JC, Hérault JP, et al. Contribution of erythrocytes to thrombin generation in whole blood. Thromb Haemost. ;81(3) 

Erlandsson E, Winstedt D, Tornqvist F, et al. Fibrinogen – väsentlig faktor nära massiv blödning. Läkartidningen.

;(44) ?articleId=

Lacroix J, Hébert PC, Hutchison JS, et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J tillsammans. ;(16) 

Yang CJ, Hsiao KY, Su IC, et al. The association between anemia and the mortality of severe traumatic brain injury in emergency department. J Trauma. ;71(6):E 

Floccard B, Rugeri L, Faure A, et al.

Early coagulopathy in trauma patients: an on-scene and hospital admission study.

En snabb puls kan vara kroppens kompensationsmekanism för minskad hjärtminutvolym orsakad av till exempel hypovolemi, hjärtsvikt och sepsis

Injury. ;43(1) 

Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. ;(3):CD 

Morrison JJ, Dubose JJ, Rasmussen bladte, et al.

Blodtrycket kan vara normalt eller lätt sänkt, pulsen har ökat till > /min

Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. båge Surg. ;(2) 

Shakur H, robert inom, Bautista R, et al.

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled rättegång. Lancet. ;() 

robert inom, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled rättegång.

Lancet.

20 % Matt, oro, yrsel, takykardi, sjunkande blodtryck, minskad diures

;(), e 

Dewan Y, Komolafe EO, Mejía-Mantilla JH, et al. CRASH-3 – tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled rättegång. Trials. ; 

Beno S, Ackery AD, Callum J, et al. Tranexamic acid in pediatric trauma: why not?

Crit Care. ;18(4) 

Eckert MJ, Wertin TM, Tyner SD, et al. Tranexamic acid ledning to pediatric trauma patients in a combat setting. J Trauma Acute Care Surg. ;77(6) 

Ho KM, Leonard AD. Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesth Intensive Care. ;39(1)

Hayakawa M, Gando S, Ono Y, et al.

Fibrinogen level deteriorates before other routine coagulation parameters and massive transfusion in the early phase of severe trauma: a retrospective observational study. Semin Thromb Hemost. ;41(1) 

Maegele M, Zinser M, Schlimp C, et al. Injectable hemostatic adjuncts in trauma: fibrinogen and the FIinTIC study. J Trauma Acute Care Surg. ;78(6 Suppl 1):S 

Knudson MM, Cohen MJ, Reidy R, et al.

Trauma, transfusions, and use of recombinant factor VIIa: a multicenter case registry report of patients from the Western Trauma Association. J Am Coll Surg. ;(1) 

Boffard KD, Riou B, Warren B, et al. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.

J Trauma. ;59(1); discussion  

Svensson PJ, Eriksson B. Studier från antidoter mot NOAK visar goda effekt. Läkartidningen. ;DAXX. 

Mitra B, O’Reilly G, Cameron P, et al. Effectiveness of massive transfusion protocols on mortality in trauma: a systematic review and meta-analysis. ANZ J Surg. ;83(12) 

Waters JH.

Role of the massive transfusion protocol in the management of haemorrhagic chock. Br J Anaesth. ;(Suppl 2):ii 

Maegele M, Lefering R, Wafaisade A, et al. Revalidation and update of the TASH-Score: a scoring struktur to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury. Vox Sang. ; 

Lier H, Krep H, Schroeder S, et al.

Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. ;